This book features high-quality research papers presented at the International Conference on Computing and Machine Learning (CML 2025), organized by the Department of Computer Applications, Sikkim Manipal Institute of Technology, Sikkim Manipal University, Sikkim, India, during March 22–23, 2025. The book presents diverse range of topics, including machine learning algorithms and models, deep learning and neural networks, computer vision and image processing, natural language processing, robotics and automation, reinforcement learning, big data analytics, cloud computing, Internet of things, human–robot interaction, ethical and social implications of AI, applications in health care, finance, and industry, computer modeling, quantum computing, high-performance computing, cognitive and parallel computing, cloud computing, distributed computing, embedded computing, human-centered computing, and mobile computing.