Over the past 15 years researchers have made enormous gains in understanding the various aspects of tyrosine phosphoprotein phosphatases (PTPases), with particularly important insights into their molecular biology, biochemistry, and role in cellular physiology. This new edition of Tyrosine Phosphoprotein Phosphatases provides a practical and accessible guide to this major family of proteins. Topics discussed include the sequence, structure, and biochemical properties of PTPases, regulation of PTPase expression, substrate preferences and catalytic mechanisms, physiology, covalent modification, modification by chemical agents and proteolysis, and interactions with other proteins, peptides, and macromolecules. Featuring comprehensive coverage of the subject, including an extensive bibliography, this volume will provide an important resource for researchers and graduate students in molecular biology and biochemistry.