This book describes the basic facilities required for surgery on farm animals. The approach and selection of animals for experiments is defined, and animal welfare is discussed. Instructions are given for the catheterization of blood vessels to allow collection of specific blood samples or tomake defined infusions into an organ or gland. The surgical exteriorization of vessels in skin-covered loops is described, as well as fistulation of the alimentary tract, allowing sampling of the digested contents and providing access to the secretions from the ducted glands. Direction to obtainaccess to the lymphatic system for the implantation of electrodes in the smooth muscle of the intestine, and for the excision of endocrine gland and the physical transplantation of the glands to provide access to their blood supply are given. Surgery of the uterus and of the fetus is described. The book advocates the highest standard of endeavor in the pursuit of research objectives requiring the use of surgical preparation in the experimental farm animal. Most of the techniques described have been successfully performed by the author and provide satisfactory survival and standardrepeatable animal preparations. This reduces the possible suffering of the experimental animal and the number of animals required to obtain meaningful results. It also enhances the scientific value by the repeatability of the results.