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From the Introduction... There were systems of knowledge we call ‘sciences' before 1572, but the only one which functioned remotely like a modern science, in that it had sophisticated theories based on a substantial body of evidence and could make reliable predictions, was astronomy, and it was astronomy that was transformed in the years after 1572 into the first true science. What made astronomy in the years after 1572 a science? It had a research programme, a community of experts, and it was prepared to question every long-established certainty (that there can be no change in the heavens, that all movement in the heavens is circular, that the heavens consist of crystalline spheres) in the light of new evidence. Where astronomy led, other new sciences followed.