The investigation and treatment of hypertension, a leading risk factor for cardiovascular disease throughout the world, remains a challenge, even in developed countries. Although antihypertensives have been available for 50 years, the rational and effective use of the myriad of existing drugs remains a concern, as does the desire to identify patients with secondary hypertension from the mass of individuals with primary or essential hypertension.The aim of this handbook is to provide state-of-the-art information concerning the pathophysiology, diagnosis, investigation, and management of hypertension in the 21st century. The book covers the underlying physiological, genetic, and environmental components that may contribute towards its pathogenesis, as well as the currently available therapies and clinical trials in hypertension. The chapters are clearly laid-out and written for the non-expert, but contain sufficient detail to serve as a useful reference for the experienced physician. The book is completely up-to-date and evidence-based, while the authors are recognized experts in hypertension based at one of Europe's leading hypertension centers.