This title comprises 50 specially written chapters on René Descartes (1596-1650) and Cartesianism, the dominant paradigm for philosophy and science in the 17th century, written by an international group of leading scholars of early modern philosophy. The first part focuses on the various aspects of Descartes's biography (including his background, intellectual contexts, writings, and correspondence) and philosophy, with chapters on his epistemology, method, metaphysics, physics, mathematics, moral philosophy, political thought, medical thought, and aesthetics. The chapters of the second part are devoted to the defense, development and modification of Descartes's ideas by later generations of Cartesian philosophers in France, the Netherlands, Italy, and elsewhere.