Dental plaque is a biofilm that forms naturally on the surfaces of exposed teeth and other areas of the oral cavity. It is the primary etiological factor for the most frequently occurring Oral diseases, such as dental caries and periodontal disease. Adequate control of biofilm accumulation on teeth has been the cornerstone of prevention of periodontitis and dental caries. Mechanical plaque control is the mainstay for prevention of oral diseases, but it requires patient cooperation and motivation; therefore, act as chemical plaque control agents adjuvants useful for achieving the desired results. Hence, it is imperative for the clinician to update their knowledge in antiplaque agents for the chemical and other developments effective management of plaque biofilm-associated diseases. This book explores the critical analysis of various chemical Plaque control strategies and the current trends in the control and prevention of dental plaque biofilm.