As health improvement initiatives take center stage worldwide, public health professionals face an ongoing challenge to prove that the programs are worthwhile and that interventions can make a positive impact on health and well-being. The Global Programme on Health Promotion Effectiveness (GPHPE) of the International Union for Health Promotion and Education takes on this challenge in Global Perspectives on Health Promotion Effectiveness. Fifty-five contributors representing six continents come together to analyze major programs from around the world and evaluate their effectiveness. Global Perspectives on Health Promotion Effectiveness is a significant document with profound implications for practitioners involved in implementing health promotion programs. It will serve as a vital source of frontline knowledge for researchers and students of public health.