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<p>The International Symposium on Symbolic and Algebraic Computation (ISSAC) is the premier conference for research in symbolic computation and computer algebra. ISSAC 2018, to be held at the City University of New York, New York City, USA, is the 43rd meeting in this series. The series has been held annually since 1981. ISSAC is sponsored by the Association for Computing Machinery (ACM) and its Special Interest Group on Symbolic and Algebraic Manipulation (SIGSAM), and is generously supported by several other institutions and organizations, which are listed in the following pages.</p> <p>This year's meeting takes place from the 16th to the 19th of July 2018. The ISSAC meeting is a showcase for original research contributions on all aspects of computer algebra and symbolic mathematical computation, including:</p> <ul> <li>Algorithmic aspects</li> <li>Exact and symbolic linear, polynomial, and differential algebra</li> <li>Symbolic-numeric, homotopy, perturbation, and series methods</li> <li>Computational algebraic geometry, group theory, number theory, quantifier elimination, and logic</li> <li>Computer arithmetic</li> <li>Summation, recurrence equations, integration, and solution of ODEs and PDEs</li> <li>Symbolic methods in other areas of pure and applied mathematics</li> <li>Complexity of algebraic algorithms and algebraic complexity</li> <li>Software aspects</li> <li>Design of symbolic computation packages and systems</li> <li>Language design and type systems for symbolic computation</li> <li>Data representation</li> <li>Considerations for modern hardware</li> <li>Algorithm implementation and performance tuning</li> <li>Mathematical user interfaces</li> <li>Use with systems for, e.g., digital libraries, courseware, simulation and optimization, automated theorem-proving, computer-aided design, and automatic differentiation</li> <li>Application aspects</li> <li>Applications that stretch the current limits of computer algebra algorithms or systems, use computer alg