Author Description

Describes molecular connectivity as a structure-based approach to biological quantitative structure activity (QSAR). Significant advances which have occured over the last 10 years in methodology and its signifiance are covered along with more recent advances in the area of electronic description Some examples of quantitative structure-activity relationships are presented which reveal the value of the method in biological studies. New research is presented, particularly in the areas of shape definition, aromaticity, and molecular flexibility.