Today, ICT has enlarged its horizons and it is practiced under multidisciplinary contexts that introduce new challenges to theoretical and technical approaches. The most critical benefit of introducing new ICT technologies in our real world living are the new ways of working that the online world makes possible. Complexity, uncertainty and scaling issues of real world problems as well as natural phenomena in ecology, medicine and biology demanding ICT assistance create challenging application domains for artificial intelligence, decision support and intelligent systems, wireless sensor networks, pervasive and ubiquitous computing, multimedia information systems, data management systems, internet and web applications and services, computer networks, security and cryptography, distributed systems, GRID and cloud computing. This book offers a collection of papers presented at the First International Conference on ICT Innovations held in September 2009, in Ohrid, Macedonia. The conference gathered academics, professionals and practitioners willing to report their recent success stories with valuable experiences in developing solutions and systems in the industrial and business arena especially innovative commercial implementations, novel applications of technology, and experience in applying recent ICT research advances to practical situations. A special attention on this conference was given to the application of new technologies in eco-informatics and bio-informatics. Prof. Danco Davcev is a Professor at the Computer Science Department at Faculty of Electrical Engineering and Information Technologies at Ss. Cyril and Methodius University, Skopje, Macedonia. Prof. Jorge Marx Gomez is a Professor at the Department of Computer Science at Carl von University, in Oldenburg, Germany.