The Multichain Interleukin-2 Receptor: From the Gene to the Bedside (T. Waldmann). Anion-Exchange and Glucose Transport Proteins: Structure, Function, and Distribution (H. Lodish). Ionic Channels: Molecular Pores of Excitable Membranes (B. Hille). Mechanisms of Human beta;-Interferon Gene Regulation (T. Maniatis). Protein Tyrosine Kinases, Protein Serine Kinases, and the Mechanism of Action of Insulin (O. Rosen). Biologic Catalysis by RNA (T. Cech). The Production of Phosphoinositide-Derived Messenger Molecules (P. Majerus). Why Study the Cytoskeleton in Yeast? (D. Botstein). Cumulative Author Index.