This document represents a summary of medical and scientific evaluations conducted on board the Zero G and other NASA sponsored aircraft from June 2011 to June 2012. A general overview of investigations manifested and coordinated by the Human Adaptation and Countermeasures Division is included. A collection of brief reports that describe tests conducted on board the NASA sponsored aircraft follows the overview. Principal investigators and test engineers contributed significantly to the content of the report describing their particular experiment or hardware evaluation. Although this document follows general guidelines, each report format may vary to accommodate differences in experiment design and procedures. This document concludes with an appendix that provides background information concerning the Reduced Gravity Program. Overview of Reduced Gravity Flight Activities * Gravitational Modulation of Calcium Signaling in Bone * Plant Viability for a NanoRack Food Growth Chamber * Water Purification and Ion Removal Through Low Pressure Distillation * Effect of Microgravity on Spinal Expansion * Hydrofuge Alpha and Bravo Plant Chambers * Aquaponics * Frying an Egg in Space