This Special Issue, titled "Innovative Material Design and Nondestructive Testing Applications for Infrastructure Materials", showcases cutting-edge research and technological advancements in the field of infrastructure materials. Featuring ten high-quality research articles developed over the course of nearly a year, this collection spans a diverse range of topics in innovative material design and nondestructive testing techniques. Contributions from more than 40 authors representing various organizations provide comprehensive insights and perspectives in this rapidly evolving and critical area of study.