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Sickle cell anemia is a genetic disease that occurs because the disease genes are passed on from both parents.Because of the short life of diseased blood cells, the spleen works to compensate the body for this deficiency, and this intense pressure on the work of the spleen causes damage to its functional performance as an organ that protects the body from infections, so patients are more susceptible to inflammatory diseases.The reduced flexibility of sickle cells in the case of anemia leads to blockages in the capillaries, impeding the supply of blood to the body tissues. These blockages cause severe pain, and in serious cases may cause infarctions, which leads to the affected organs losing their ability to perform their functional tasks, and side problems associated with anemia such as fatigue, and delays in growth and development may also appear.