This book covers selected research works presented at the fifth International Conference on Networking, Information Systems and Security (NISS 2022), organized by the Research Center for Data and Information Sciences at the National Research and Innovation Agency (BRIN), Republic of Indonesia, and Moroccan Mediterranean Association of Sciences and Sustainable Development, Morocco, during March 30–31, 2022, hosted in online mode in Bandung, Indonesia. Building on the successful history of the conference series in the recent four years, this book aims to present the paramount role of connecting researchers around the world to disseminate and share new ideas in intelligent information systems, cyber-security, and networking technologies. The 49 chapters presented in this book were carefully reviewed and selected from 115 submissions. They focus on delivering intelligent solutions through leveraging advanced information systems, networking, and security for competitive advantage and cost savings in modern industrial sectors as well as public, business, and education sectors. Authors are eminent academicians, scientists, researchers, and scholars in their respective fields from across the world.