This book presents the latest advances and research achievements in the fields of autonomous robots and intelligent systems, presented at the IAS-16 conference, conducted virtually in Singapore, from 22 to 25 June 2021. IAS is a common platform for an exchange and sharing of ideas among the international scientific research and technical community on some of the main trends of robotics and autonomous systems: navigation, machine learning, computer vision, control, and robot design—as well as a wide range of applications. IAS-16 reflects the rise of machine learning and deep learning developments in the robotics field, as employed in a variety of applications and systems. All contributions were selected using a rigorous peer-reviewed process to ensure their scientific quality. Despite the challenge of organising a conference during a pandemic, the IAS biennial conference remains an essential venue for the robotics and autonomous systems community ever since its inception in 1986. Chapters 46 of this book is available open access under a CC BY 4.0 license at link.springer.com