This book presents cutting-edge research and developments in the field of medical and biological engineering, which a special emphasis on activities carried out in the Asian-Pacific region. Gathering the proceedings of the 12th Asian-Pacific Conference on Medical and Biological Engineering (APCMBE 2023), held on May 18–21, 2023, in Suzhou, China, this first volume of a two-volume set focuses on biomedical imaging and signal processing, biomedical sensing and wearables, and rehabilitation and neural engineering. All in all, this book offers extensive information on the state-of-the-art solutions and challenges in biomedical and clinical engineering, addressing a broad audience of medical scientists, engineers, physicists and other researchers and professionals.