This book is a compilation of selected papers from the 3rd International Symposium on Software Reliability, Industrial Safety, Cyber Security and Physical Protection of Nuclear Power Plants, held in Harbin, China on 15th–17th August 2018. The symposium discussed the status quo, technical advances and development direction of digital instrument control technology, software reliability, information security and physical protection in the process of nuclear power development. Offering technical insights and know from leading experts, this book is a valuable resource for both practitioners and academics working in the field of nuclear instrumentation, control systems and other safety-critical systems, as well as nuclear power plant managers, public officials, and regulatory authorities.