The built environment has profoundly shaped human health, influencing physical, psychological, and social well-being. This Special Issue, Advances of Healthy Environment Design in Urban Development, compiles 18 studies that address urgent challenges in urban health through innovative design strategies, interdisciplinary methods, and evidence-based solutions. Advances of Healthy Environment Design in Urban Development synthesizes global expertise to chart a path toward healthier, more equitable cities. By redefining the role of the built environment as both a determinant and enabler of health, this collection empowers stakeholders to prioritize human well-being in urban agendas. From adaptive vernacular architecture to AI-driven design tools, the studies herein illustrate that health-centric urbanization is not merely aspirational-but achievable through collaborative innovation, evidence-based policymaking, and community engagement. As cities continue to evolve, this Special Issue serves as a critical reference for transforming urban spaces into engines of holistic health, resilience, and social vitality.