A companion to the London Dysmorphology Database, the new 2000 edition of the London Neurogenetics Database covers in more substantial detail clinical neurological features, neuroradiology, neurophysiology, and neuropathology including nerve and muscle biopsy findings. Details of 2,953 syndromes involving the central and peripheral nervous system are now held in the Windows version and there are 32,441 references. <P>The database is simple to use and has many invaluable features. You can browse or search for the syndromes, features, and references supplied. Searches can be combined or progressively refined, and you can print or save searches at the click of a mouse. <P>New features of the 2000 database include a direct link from the database to the Online Mendelian Inheritance in Man (OMIM) web site and also to the Medline site. From the OMIM site other molecular databases and information can easily be accessed and the Medline links will allow access to full abstracts for cited papers. <P>Free online updates for all purchasers of version 2.2 All purchasers of this new version will have access to a free online updating service. Updates will be placed at regular intervals on our web site. Users can dowload these updates, and by simply clicking a button, integrate them into their database.