This book CCIS constitutes the refereed proceedings of the First International Conference on Applied Artificial Intelligence, 2AI 2024, held in Solan, India, during July 2–4, 2024. The 26 full appers and 4 short papers were carefully reviewed and selected from 151 submissions. The proceedings focus on AI for Healthcare, AI for Business and Finance, AI for Defense and Information Security, AI for Agriculture, AI for Education.