The 2nd Universitas Kuningan International Conference on System, Engineering, and Technology (UNISET) will be an annual event hosted by Universitas Kuningan. This year (2021), will be the second UNISET will be held on 2 December 2021 at Universitas Kuningan, Kuningan, West Java, Indonesia. “Opportunity and challenge in environmental, social science and humanity research during the pandemic Covid-19 era and afterward” has been chosen at the main theme for the conference, with a focus on the latest research and trends, as well as future outlook of the field of Call for paper fields to be included in UNISET 2021 are: natural science, education, social science and humanity, environmental science, and technology. The conference invites delegates from across Indonesian and South East Asian region and beyond, and is usually attended by more than 100 participants from university academics, researchers, practitioners, and professionals across a wide range of industries.