Lee Casey plays guitar in a noise band called Ottermeat on the verge of leaving its home in New Jersey, in hopes of somehow making it in Los Angeles. For now Lee is squatting in a dilapidated house, and working off the books as a stone mason. He drives a pickup truck he crashes into everything and everyone. As a close friend overdoses in his sleep, Lee begins a strange relationship with two college girls, June Doom and K Neon. F-250 is a novel as equally about growing up as it is about being torn apart.