The present reprint contains a total of 13 articles published in the Special Issue "Advances in Mathematical, Numerical and Artificial Intelligence Methods in Rock Engineering Applications" of the MDPI journal Mathematics, covering a wide range of topics connected to the latest applications of mathematical, numerical, and artificial intelligence methods in rock engineering, aiming to contribute to addressing rock-related issues. These topics cover the constitutive modeling and failure criteria of rock materials; theoretical and analytical approaches for deformation, fracture, and failure in rocks; numerical simulation of stress-physical-chemical coupling processes in rocks; theoretical, analytical, and numerical approaches for understanding time- or size-dependent rock failure; characterization of multi-scale rock damage and fracturing; and mathematical methods revealing the mechanisms behind rock disasters that are useful in establishing the associated criteria. The reprint is intended to provide interesting and useful insights for those working in the fields of rock mechanics and rock engineering.