Developing the essential theory for architecting and tackling issues faced during complex realistic engineering problems, this volume focuses on enhanced anti-disturbance control and filtering theory and applications. The book specifically addresses the novel disturbance observer based control (DOBC) methodologies for uncertain and nonlinear systems in time domain. It also examines novel anti-disturbance control and filtering with the composite hierarchical architecture to enhance control and filtering for the complex control systems with multiple disturbances. The book provides application examples, including flight control, robotic system, altitude control, and initial alignment to show how to use the theoretical methods in engineering