Advances made so far in the worldwide study of AIDS and HIV owe much to our knowledge of T-cell leukaemia, which is the first human cancer known to be caused by a retrovirus. This book records the state-of-the-art findings on ATL and related diseases, and reviews the information which has been accumalated over the past two decades. Contributions from leading experts cover haematology, neurology, virology, epidemiology, pathophysiology, animal models, and treatment of ATL. The major contribution of ATL research to the understanding of AIDS, another retrovirus-caused disease, is clearly highlighted in this book.Contents include: ATL and HTLV-I-related diseases; regulation of HTLV-I-gene expression and its roles in ATL development; epidemiology of HTLV-I and HTLV-II infection; ethnoepidemiology of ATL in Japan, with special reference to mongoloid dispersal; ATL of Caribbean origin; molecular epidemiology of HTLV-I and HTLV-II; HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP); pathophysiology of ATL cells; cell growth characteristics; animal models of HTLV-1 infection; chemotherapy of ATL, and new approaches to the treatmant of ATL.